Kay's Science

I wonder if someone saw the Twilight Zone episode Twenty-Two…

2012-02-05T15:50:00.001-05:00

And then I individually counted them, numbering thirty-two. This seemed odd to me, and so I left the room and at the top of my staircase (this time perfectly resembling in all sensory aspects my actual staircase - not the one from beforehand) called out to my Mom downstairs, asking her why there were so many pizza boxes in the spare bedroom.

I’m thinking here this guy is really starving and wants to eat more… | Kay's Science

…and thought one of the women was a perfect 10.

My experience with taking BCAA’s before bed…

2012-02-05T15:15:00.001-05:00

Taking BCAA's before bed?

« on: January 26, 2011, 08:09:46 AM » most people use them intra-workout like myself, or sometimes even pre/post workout. but would it be beneficial to take BCAA's before bed? i know alot of people take Casein before bed, how would taking a BCAA drink pre-bed compare in over-night recovery?

« Last Edit: January 26, 2011, 08:11:19 AM by venom434 »

Taking BCAA's before bed?

I think it depends on the amount you take. I have consumed too much and I was unable to sleep, despite documentation that Leucine is a precursor to glutamate which is a precursor to GABA if enough glutamine is available, GABA being an inhibitory neurotransmitter partly responsible for the onset of sleep and relaxation. I had read numerous articles about the BCAAs being processed in muscle tissue as opposed to the liver. Based upon this information I consumed a higher than normal amount of BCAAs early in the afternoon. I had serious difficulty getting to sleep and had to get a prescription drug to help protect my brain and help me sleep. This was due to glutamate toxicity in the brain. Glutamate toxicity can have serious consequences resulting in neuronal death. I have since taken much smaller doses and I have had no problem.

Journal of Biological Chemistry - Regulation of Protein Synthesis in Heart Muscle, Effect of Amino Acid levels on Protein Synthesis

These studies indicated that protein synthesis in heart muscle could be stimulated by raising perfusate amino acid levels above those normally found in rat plasma. Although net uptake of isoleucine and leucine was observed, suggesting that these amino acids were used as oxidative substrate, the increased rate of synthesis appeared to be due to a direct effect on the pathway of protein synthesis rather than an indirect effect mediated by changes in energy levels of the cell.

My understanding about leucine is that it initiates protein synthesis (translation) which means it triggers protein folding and this is the process by which all proteins including muscle protein are made in the body. It starts the process for the body to build various proteins like actin and myosin, proteins which make up muscle tissue. Over loading your body with leucine can have serious consequences as well, unless you are working out regularly and using up these proteins for carbohydrates and ATP. Since the body requires ATP and glucose is the favored source for ATP, our body will use protein to create glucose before it will burn fat. Unless you are consuming a higher than average quantity of protein, you will suffer from muscle wasting if you are trying to burn fat. The RDA for the BCAAs is 50 times lower than what some body building sites suggest. For a female not lifting weights regularly and wanting to weigh about 125 lbs, I figured out 3 grams daily would be enough for me. I eat complex carbohydrates to prevent protein from being catalyzed for glucose. It’s a lot less expensive than consuming protein for glucose via gluconeogenesis although this is the recommended pathway for burning fat and a more frequent protein turnover, although you are using .7 grams of the protein you eat for glucose which would go directly to the brain first then ATP. All I did was calculate how many carbs I would need to consume to stay within the recommended dosages of protein and then from that deduced how many amino acids I would need to meet daily requirements. I do consume protein from food sources as well.

75 grams of protein x .7 = 52.5 gms carbs from protein. 75 – 52.5 = 22.5 gms amino acids. Divide 23 by 8 essentials = ~3gms of each amino.

I have cut my consumption of the BCAAs to 1/2 teaspoon of the GNC product I use, two or three times per day. I get the other essential amino acids from Jo Mar Labs, a small business in Campbell, CA with an office here in Chapel Hill, NC. I have also used Jo Mar Labs BCAAs I like because they are in much lower quantities and equal amounts of each. The risk of getting to much isoleucine is much lower. Isoleucine contributes to blood coagulation. It is also both glucogenic and ketogenic. This is a necessary consideration for smaller bodies.

Not only did I experience sleeplessness after consuming the high dose of BCAAs (10 grams of leucine) but I observed as a result more flabby muscle in the triceps. I wondered if this was from too much glutamate. I was consuming foods high in fat so my thinking was since the BCAAs are hydrophobic, it might also help prevent the clogging of my arteries, pulling the fat into the tissues rather than letting it collect on artery walls. I don’t know if it lowers cholesterol as leucine promotes the production of cholesterol, how much I cannot say.

I will also mention that it has been stated growth hormone is released during sleep. I have read nothing which states the consumption of protein or BCAAs interferes with this release but this might be a consideration since it is the night time fasting which actually triggers the release of HGH.

Again while BCAAs are not synthesized in the liver, according to the article above, nor does their consumption increase energy levels in the muscle cells so overconsumption is of no use to the body and may cause harm. Over consumption of protein can cause other problems such a dehydration, kidney problems and other conditions. There is really no fast track to weight loss or body building. Monitoring food intake, regular exercise and discipline are the key to success. It is advisable to consult a nutritionist or sports nutritionist regarding protein and other dietary needs while dieting or bodybuilding.

A question…

2012-01-08T22:39:00.001-05:00

Why does tyrosine zap my appetite? It isn’t neuroinhibitory like melatonin or some psychotropics or is it? Whenever I take it I have a loss of appetite but it raises my levels of alertness and aggression for survival, not violence.

I experienced this while coming down from PCP…updated

2012-01-08T22:18:00.001-05:00

perceiving the world around me in a sort of tunnel vision.

Erowid Experience Vaults: Melatonin - The Reality from Behind Closed Eyelids - 89425

…I would argue that melatonin alters one’s reality. It is clear his thoughts are a bit disorganized and he simply needs to work through his dream to do that, put things in perspective as he did for some of the dream content.

I’m thinking here this guy is really starving and wants to eat more…

2012-01-08T22:08:00.001-05:00

When I opened the door to the room, however, I didn't see the familiar twin beds set aside by the window. What I did see, however, were many semi-empty pizza boxes. (It's funny to note that before sleeping I had eaten a couple slices of pizza from a pie that I had bought at a nearby Costco.) The boxes were stacked on top of each other, all around the room. I opened up a few to see a couple pizza slices or crusts here or there. And then I individually counted them, numbering thirty-two. This seemed odd to me, and so I left the room and at the top of my staircase (this time perfectly resembling in all sensory aspects my actual staircase - not the one from beforehand) called out to my Mom downstairs, asking her why there were so many pizza boxes in the spare bedroom.

Erowid Experience Vaults: Melatonin - The Reality from Behind Closed Eyelids - 89425

…than he will permit himself to.

Wow!

2012-01-08T21:41:00.001-05:00

Erowid Experience Vaults: Melatonin - The Reality from Behind Closed Eyelids - 89425

This is what I am talking about, these kinds of experiences but not acting them out. This person seems to me to also be experiencing memories of his birth experience, ie, panic attacks.

If one looks carefully at this picture one might think it was the head of a baby leaving the birth canal. I came to this realization a few days ago and could not stop laughing. I had created that hair style around my face. I had also connected a dream experience of Leonardo’s about a turkey feather to this birth experience. Albrecht Durer painted it.

Response to reading Erowid poster on Melatonin…

2012-01-08T21:13:00.001-05:00

As it turns out, melatonin has been hyped somewhat as enhancing the clarity and intensity of dreams. This intrigued me because I typically have very vivid and realistic dreams in the first place. Could melatonin somehow make them more realistic still? Furthermore, if I had the good fortune to recognize such a dream and allow it to become a lucid one, would it be that much better with the help of melatonin?

Erowid Experience Vaults: Melatonin - Interesting Effects on Sleep and Dreaming - 69353

I think it is what you put into your mind and what you are consuming while you do it that has an effect on how well you process and recall that information. I don’t think the melatonin has anything to do with dream clarity. Being jerked awake again seems like something to do with what has been put into the brain and mind which could take days or weeks to affect one’s behavior.

My biggest problem with Melatonin has been the rebound effect, which is a period of sleeplessness after ceasing the substance. After perusing Erowid I started to wonder if melatonin was similar to LSD or if LSD was a kind of precursor to melatonin in the brain.

My LSD experience was brief and disturbing because I had maintained a tight control on my thinking and behavior for a long time due to traumatic experiences and then was lifted from those experiences and into unfamiliar territory. What I learned was significant and what later unfolded in my personal life was certainly related to that experience. I was not out of control while taking it but my fear kept me from fully grasping and appreciating the reality of what I was experiencing. I can see how people can jump from windows trying to escape something in their mind while doing this substance. It should never be done unsupervised by someone professional. I am guessing it is similar to Prozac as well.

A PCP experience proved fruitful in revealing the content of the mind, but caused me to act out that content rather than see it clearly as the LSD did. Melatonin has permitted me to see, as in remote viewing. No other substance has worked this well for me. I have found there are other things like diet which had an effect on my ability to sleep and stay asleep. Too much protein before bed without glutamine keeps me awake. Too much histamine or too much milk both have an affect on my ability to sleep and in that case I take an anti-histamine like Chlorpheniramine Maleate with the melatonin and/or glutamine. Taking melatonin internally has a powerful effect but under the tongue is much faster. The melatonin/chlorpheniramine combo is better than Abilify. The downside is loss of appetite but since melatonin doesn’t last long in the body this isn’t too much of a problem.

I do not advocate the use of LSD or PCP for these purposes.

ATP and Osteoporosis…

2012-01-04T00:27:00.001-05:00

I wonder if osteoporosis is actually caused by adenosine triphosphate since phosphates are part of the bone building process. ATP is stealing phosphates from bone to make ATP especially when carbs are high and high levels of energy are needed. I suspect women who are raising children and have busy active lives such as working while raising them set the stage for osteoporosis especially if their diets don’t have adequate supplies of foods containing phosphorous or calcium such as legumes.

Is it estrogen or the bodies higher protein requirements?

2011-12-19T14:53:00.001-05:00

In order to make estrogen, the cells have to store more fat.

Estrogen Changes During Weight Loss | eHow.com

In order to make more estrogen the body will require more protein and this means higher fat absorption.

This might explain post menopausal weight gain…

2011-12-19T14:50:00.001-05:00

Estrogen Controls Branched-Chain Amino Acid Catabolism in Female Rats

…since BCAAs are all very hydrophobic [fat absorbing].

This is an interesting article…

2011-12-19T13:35:00.001-05:00

Excess Estrogen and Weight Gain: A Nutrition article from Dragon Door Publications | Health and Nutrition - News | Dragon Door

After reading this it has become clearer to me that viewing too much television or listening to too much music often prompts the need to take some kind of neuroinhibitory drug such as benzodiazepines or their derivatives. This in turn might affect estrogen levels and cause excessive weight gain even in a young person. Sleeping too much might also cause the problem.

I was given Phenobarbital and Donnatal in high school for acute seizures. In college I developed endometrial hyperplasia, an overgrowth of the uterine lining. I was never told it was from too much estrogen though. So this article and other articles about melatonin make me think the drugs might have caused this problem.

I have been taking melatonin for several years now…

2011-12-19T13:08:00.001-05:00

…I stopped taking it for a few days and I started experiencing menstrual bleeding just a few days ago, however it was of a very short duration. This is the second time it has happened.

Free Form Aminos vs Protein Peptides…

2011-12-11T14:15:00.001-05:00

I thought peptides are often actually up-taken faster (than free form aminos) due to specific peptide receptors in the gut. At least this is how it works in general and there may be some aminos that absorb faster than a peptide.

TESTOSTERONE NATION | Amino Acids: Peptide Bond vs. Free Form - Page 1

I have been researching this topic but not with regards to absorption as much as about protein folding. After thinking through the process of protein digestion I came to the conclusion that free form aminos should fold just as any of the amino acids broken down from say a steak after it has been digested.

When I read this response I thought it in error as the issue is absorption so their should be no peptide receptors in the gut related to absorption. Peptides like other proteins have to be broken down further as mentioned in a previous response and then absorbed so actually amino acids would be absorbed faster as they skip this step. Once they are absorbed, then they are folded into their respective conformations as needed by the body and then shuttled off where they are designed to fit into various receptors. I read a sports nutrition book discussing IGF 1 from bovine sources compared to human sources and the author, a sports Doctor, stated the bovine source was not identical to the human source so it was basically not affective. Apparently they were talking about IGF injected into the body rather than ingested via the mouth as even bovine IGF 1 will be broken down into its separate amino acids and then refolded into those needed by the human body. I did read that sometimes these peptides do get through the gut as peptides and can trigger inflammation which would then be attacked by chaperones and ubiquitin, unfolded and then refolded.

I do not use whey anymore because it contains the faster absorbing proteins and this means that the stimulating aminos hit the central nervous system faster and can cause damage as they are absorbed more quickly than casein. I have developed hyperactivity and other symptoms from using whey. I am not a body builder so there is no need for me to consume large quantities of whey.

I have taken amino acids for about 20 years in various forms, even too much of those can cause a problem. I have found them to be more helpful to me and my needs at this time.

I think this is true for humans…

2011-12-09T22:26:00.001-05:00

SpringerLink - Neurophysiology, Volume 35, Number 1

Yesterday I took about 150 grams of maltodextrin with a full spectrum of essential amino acids, about 3 grams each. I only took 500 mgs of tryptophan. Last night I took a 2.5 mg melatonin under the tongue. After a few hours I fell asleep and did not wake up until 10:00 AM. I had the best nights sleep I think I’ve ever had. I recollect what I was thinking before falling asleep but I recall no dreams at all.

My thinking on the ketogenic diet is - 3rd revision…

2011-12-06T13:43:00.001-05:00

Evolutionary Psychiatry: Your Brain on Ketones

…that any excitatory aminos consumed from protein such as whey is going to get converted to glucose rather than getting used by the CNS for neurotransmitters, if no carbs are consumed or low carbs are consumed, particularly of you are an active person. This means fewer excitatory aminos in the central nervous system.

I’ve had a problem getting my body into a state of lipolysis, even to the point of lowering leucine levels so it wouldn’t be stored in adipocytes, like those most found around the abdomen (mostly found on women as protection when pregnant). Unless you are consuming high quantities of protein your body could start breaking down muscle tissue (as mine once did) for carbohydrates as the brain favors carbs for fuel, not enough and brain damage could result. Since lipolysis is a much slower process, carbs via gluconeogenesis will be created much faster which means muscle wasting. Adding large doses of leucine only means more protein synthesis and that could mean breaking down muscle.

I ate lots of fat when I was younger. I didn’t eat lots of protein. I got thin and so did my musculature. The key I found to reducing the brain fog when eating carbs is tyrosine derived from phenylalanine. It keeps you alert and acts like caffeine in the brain but is much better for you. Active people who know anything about their diets know that ATP is important and that carbs are the fastest at creating ATP.

Aside from this, it may be that some species (races) prefer and can utilize a higher fat content versus carbs. I’ve tried it both ways and it seems carbs work for me.

As for seizures, adenosine, the by product of ATP production is neuroinhibitory, preventing seizures. My experience with seizure has been induced either by the excitatory amino acids or by other means outside the body, glutamic acid, glutamate, aspartic acid, alanine and even histidine but not glutamine. A glass of milk can cause me excitation and usually keep me awake if consumed before bed. It should be consumed on an empty stomach. Last night I drank some Coke Zero which contains phenylalanine and aspartic acid. It kept me awake too. I consumed it too late.

Today I consumed 5 grams of phenylalanine along with the other essential aminos (no histidine) in two separate doses as free form amino acids, no aspartic acid. I am not agitated or hyper at all. I have done this frequently for more than 5 years, less frequently for longer in smaller amounts. I also took much less than the recommended dosage for the BCAAs which contains leucine that gets converted to glutamate. Leucine is necessary for protein transcription. It is the levels of circulating essential aminos which contribute to protein folding and the building of proteins which form muscle tissue and other proteins necessary for the functioning of the body.

And I have only one question, if high protein and high fat are good for you, why have heart Doctors and the AHA been telling people to stop eating beef, which can contain as much as 15 grams of saturated fat alone?

The good Doctor also failed to mention the by-product of fat breakdown is glycerol which can pull water from muscles and raise blood pressure. This is what caused Dr. Atkins’ death from a brain aneurysm. Vegetable glycerin from plant foods like celery, cucumbers and zucchini does the same thing. I remember the science class experiment we did in elementary school. A glass of water was filled with food coloring and a stick of celery was placed in the glass of water. Guess what happened? The celery absorbed the colored water.

It seems to me that economics has set the standard for health rather than what is and is not true about the foods we eat.

Who is telling the truth???????

2011-11-20T22:48:00.001-05:00

Linus Pauling Institute at Oregon State University

Dementia (Alzheimer's disease)

Alzheimer's disease has been associated with a deficit of the neurotransmitter, acetylcholine, in the brain (20). One possible cause for the acetylcholine deficit is a decrease in the expression of an enzyme that converts choline into acetylcholine in the brain. Large doses of lecithin (phosphatidylcholine) have been used to treat patients with dementia associated with Alzheimer's disease in hope of raising the amount of acetylcholine available in the brain. However, a systematic review of the randomized trials did not find lecithin to be more beneficial than placebo in the treatment of patients with dementia or cognitive impairment (21).

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

This may also be the mechanism by which I lost weight…

2011-11-09T18:38:00.001-05:00

Taurine is found at consistently high concentrations in the brain, though levels decline with age. Researchers showed that the spatial learning ability of older rats was impaired, with the impairment correlated to the reduction in taurine in the striatum of the brain (14). Aged rats with modest reductions of taurine showed only modest reductions in learning. Additionally, striatal dopamine was markedly lower in aged learning-impaired rats, demonstrating a potential interaction between taurine and dopamine that may have implications for Parkinson's Disease (see below).

CONTEMPORARY REVIEW OF THERAPEUTIC BENEFITS OF THE AMINO ACID TAURINE

…Taurine may have blocked the uptake of dopamine into the striatum, making more tyrosine available for thyroid hormone production, increasing metabolism.

I have used GABA or Glycine on the outer ear to block the pulsating in the ear…

2011-11-07T20:57:00.001-05:00

Noise at Work

…so far has been affect. Also using GABA or Glycine under the tongue helps. Of course ear plugs help when I remember to use them and they are relatively inexpensive.

After reading Ben Best’s site I have concluded…

2011-11-06T15:38:00.001-05:00

The 7 Best Brain Boosting Supplements | Live in the Now | Natural Health News | Natural Health Resources

DHA, while good for the brain at birth and in very small amounts, might contribute to Alzheimer’s and Cardiovascular disease as it oxidizes more rapidly than other fats.

I take 250 mg once or twice a week or I eat fish once a week. I never take fish oil the same week I eat fish.

Sleep…

2011-11-06T14:15:00.001-05:00

I went to bed at about 2:15 AM. I woke up at 5:40 AM to go to the bathroom. I awoke again at 8:44 AM and took a dose of B-12 then went back to sleep. I kept hearing Braerton. After about 40 minutes I was about to fall into a very deep sleep when I was suddenly awakened by this squeaking noise like a dogs toy. It ticked me off. It was the first time in years I had been able to reach that level of sleep despite the fact that it was 10:00AM.

These people who keep hijacking my psyche are not helping me they are causing a problem with my sleep and I mean to stop it.

Methylcobalamin…

2011-11-06T13:14:00.001-05:00

I am trying this supplement. I figured I was depleted of B-12 stores from poor diet, donating plasma, and abusing alcohol, which was and is now partly responsible for my depression and poor eating habits.

The first dose has a noticeable affect and definitely blocks melatonin. I also had an increase in appetite by the end of the day. My energy levels picked up late in the day as well.

After all of the blood tests I’ve had no one mentioned it.

My NCBI - Recent Activity

2011-11-05T22:03:00.001-04:00

My NCBI - Recent Activity

Biochemistry question…

2011-11-05T16:27:00.001-04:00

If methionine can form lecithin in the human body, how does homocysteine clog arteries?

Aspartic Acid and Glutamic Acid, Glutamine are the aminos found highest in proteins of all kinds…updated

2011-11-05T15:29:00.001-04:00

Aspartame Dangers and Side Effects

…Unless you are eating nothing but protein and no carbs, eating high amounts of it is going to overexcite your nervous system and even if you do eat it on an empty stomach you are going to experience some excitation. This excitation is what led me to use amino acids. Eating on an empty stomach permits the glucogenic amino acids to be converted into glucose via gluconeogenesis.

This is why there were lawsuits against companies producing aspartame.

I tried a higher protein diet and cutting the carbs but this simply did not work for me and I had already overdosed on glutamic acid once, the other reason I was taking amino acids. It did make sense that eating the protein on an empty stomach would work better but some of the peptides were so readily absorbed and faster acting that I could not use them. I wondered how so few amino acids could possibly be of benefit to good health as stated in the RDA for them and after having read many articles on various amounts of protein needed for adequate health and after having purchased them and taking them according to the RDA, I did not feel I was getting enough protein in my diet and was eating vegetarian. I did not take into account not getting enough fat or carbs. I was getting protein from other sources such as legumes and vegetables. I decided the RDA was not enough.

I will add that taking smaller amounts of the peptide proteins may be better but I still was unable to tolerate then as levels increased during the daily intake. So from my experience, whey would be contraindicated for people with autism and I would venture to say that even milk is a problem for autistics. In taking aminos I would also suggest low levels of phenylalanine which also tends to cause some excitation. Having done all of this, I have come to one conclusion I haven’t read and that is, it seems we may not even need to take in high doses of protein everyday considering all of the other things we consume such as carbs which are derived from protein as cells and some organs do store amino acids. Our bodies will signal us when we need to get more of something in our diets.

Following some of the Atkins recommendations I have put on 50 pounds of fat and now I am having a difficult time getting it off. I reduced my carbs and then my metabolism just slowed to a crawl and I have barely been getting my BMR for calories. Lipolysis takes longer to produce ATP and by the time you get enough your brain and muscle stores could be depleted and you incur brain or muscle damage, not to mention high blood pressure which can lead to aneurysm or other vascular damage. Not only does it cause those problems but one becomes more sedentary in an attempt to preserve muscle stores of glycogen and accommodate the slow production of ATP from fat. While fat may produce more ATP than carbs, it is not the bodies more advantageous source of ATP the energy of life. For one who sits behind a desk all day, a reasonable amount of fat over carbs may be the best remedy for weight gain and satiation, not for active people. My experience in the past with the higher fat, although I was not doing the Atkins it was simply what I was consuming, my body started to breakdown muscle protein to get the carbs I needed in my youth as I was more active and lipolysis was not working. I lost a lot of muscle as a result. Carbs do prevent muscle breakdown. Since some protein does get converted to glucose one could sustain themselves on a higher protein diet if one can tolerate the excitatory amino acids they contain or one finds a source that works better such as casein which contains higher levels of the essential amino acids and lower levels of the excitatory aminos. Milk protein isolate has proven to be of benefit to me and not so stimulating and I have been able to consume it at night with no problems.

Amidst all of this I viewed a film about the giant squid. Thinking about how the squid, over time, develops into a huge creature, it was clear they were doing something right, even though their brains are not highly developed. They only consume the fat from that which they eat from the ocean. They do not eat saturated fats. Their diets are mostly protein and they can get really big without fat. Realizing this I was confused about how Karen Carpenter lost her life because of a high protein diet since more than half a single gram of protein gets converted to carbohydrates in the body, presumably on an empty stomach and leucine is responsible for cholesterol production, not fat, which is necessary in the diet. This leaves one thinking that it was surely the protein that actually caused her death and particularly the excitatory amino acids.

I am sticking to my higher carb diet. It has worked for me in the past so why did I bother changing it? There was a need.

Brain and Glutamate

ABC Bodybuilding

Amino Acids and Protein for the Athlete

The Neurobiology of Human Behavior – Robert Sapolsky

Leucine and Fat Burning

What I think about manic behavior…update 4

2011-10-31T16:03:00.001-04:00

I did not consciously embark on the idea of researching any mental illness as I am not a biochemist, Doctor or neuroscientist. I was never informed of any research being done which may have influenced my actions. I was using GABA to help calm me down after having taken high doses of tyrosine and tryptophan I consumed for a clinical depression, causing my behavior to get out of hand and after having taken too much glutamic acid. I discovered glycine was neuro-inhibitory so I tried it for sleep. It does not aid in sleep even at 3 grams. It does inhibit the frequent motor activity associated with interrupted sleep.

I have found neuro-inhibitory amino acids like glycine can be the cause of manic behavior, especially when there are adequate or high levels of dopamine present. I have taken this amino acid over a period of time. It is neuro-inhibitory and seems to block motor activity when levels are high. When glycine levels are lowered, a rebound affect occurs and causes dopamine to flood synapses, which then causes one to exhibit manic behavior. The same effect can happen when someone takes cocaine that blocks the uptake of dopamine and prevents a sort of resting period after its activation in which dopamine would be taken back up into the cell. Preventing the reuptake can cause cell death from over activation.

My experience with glycine is what led me to conclude the Neanderthal developed his big brain not just from watching and hunting the woolly mammoth but from consuming the woolly mammoth containing high levels of glycine. Neanderthals often consumed the bone marrow consisting of high levels of hydrolyzed protein. Glycine is the most abundant amino acid in hydrolyzed protein. This slower activity enabled the Neanderthal’s brain time to develop before he was assaulted by a barrage of perceived threats to his existence, that would have set into motion all sorts of deadly stress chemicals.

At some point in time during their evolution the woolly mammoth must have consumed foods high in this amino acid. Continued consumption up-regulated the need for this amino acid so they then required more food with which to produce it. As they became vegetarians their levels of other amino acids like dopamine dropped off causing an imbalance in the brain.

The consumption of hydrolyzed protein by humans might have produced developmental problems such as those seen in the Elephant Man. Since my consumption of this amino acid I have developed skin growths resembling those that plagued the body of Joseph Merrick. It may also contribute to Alzheimer’s disease in which case Merrick would have been acting out something from someone else, or acting according to someone else’s will rather than from his own.

I treated the bottom left area, a much larger one, topically with black tea for 24 hours and looks worse in the photo than it really is due to camera distortions. The tea stripped the growth leaving a slightly red patch I am treating with Vitamin E.

Melatonin does not stop sound or anything which has been…

2011-10-31T14:10:00.001-04:00

What's In Kay's Mind?: Melatonin has helped stop music in the brain…

…processed by the limbic system before it it released from the pineal or ingested. From what I can tell it does not stop anything in the cortex.

This is how I was able to scald myself in the shower while in the hospital in 1989 and never feeling it…

2011-10-18T15:21:00.001-04:00

A year or so ago I discovered the film The Woman in Green, which talks about a murder, in which hypnosis

What's In Kay's Mind?

…my mother scalding her leg, the four (I failed to mention another I encountered, two were arm cutters, two were leg cutters, one was named Mary) other women cutting themselves with objects…it is hard to say how long I have been affected by the film…as I have been involved in numerous life threatening situations in which I seem to have had little fear unless I was mixed up with someone else who was more alert.

I was not taking any medications for pain.

The woman in the last segment of the sleepwalking film is acting like the characters in The Woman In Green…

2011-10-18T14:20:00.001-04:00

…in several scenes where they are walking up and down stairs.

Kay's Science: A good old fashioned cocaine cocktail…

Re: Sleepwalking - I was also suffering from sleep deprivation as I had been in the Army…update 3

2011-10-18T01:01:00.001-04:00

In 1977, after an evening out at a night club, I had a little more to drink than usual and fell asleep on the sofa. I had wet the sofa or bed in my youth and was admonished for it, so I developed repressed memories I expressed as anxiety about falling asleep and the fear of becoming too relaxed in order to keep from wetting the bed and I was a bed wetter until age 12. As a result, that night after drinking too much, I must have had to go to the bathroom, of which I have no recollection, took a white ashtray off the coffee table, placed it on the floor and urinated in it.

Kay's Science

…and had been without sleep many months before joining the Army. It grew into a serious problem since seeing The Exorcist, in 1974 which drove me to join the Army. For 6 months I had less than 4 hours of sleep a night. The less sleep I got the more angry I did become over not being allowed to sleep for one reason or another. I felt I had no control of my inability to get adequate sleep and put myself in those situations.

A year or so ago I discovered the film The Woman in Green, which talks about a murder, in which hypnosis was demonstrated to an audience and then to Sherlock Holmes’ sidekick Dr. Watson. It became clear to me, it was possible to be hypnotized by that film and I wondered had I been the victim of my mother having viewed it.

Update 2: The reason I concluded it was this film is because I had purchased a green coat several years prior to discovering this film and green isn’t even my favorite color. I later went back and purchased the same coat in black and gave the green one to my sister, who didn’t need a coat but took it anyway.

Update 3: I was also born at 14 minutes passed midnight so my natural sleep cycle is such that I should be awake at night anyway.

This leads me to think this was the reason I was in a state of hypnotic sleep, but really wide awake physically and acting out the thoughts of the person I was or am connected to in Massachusetts. I am guessing the writer who might have been penning the events resided in Chapel Hill, NC where I had visited in 1972 so the thoughts were still going on in the mind.

Melatonin under the tongue seems to be more affective at inducing sleep…updated

2011-10-16T15:41:00.001-04:00

Kay's Science: A good old fashioned cocaine cocktail…

…than taking it internally. Internal ingestion of melatonin does affect appetite in a very dramatic way. I took it internally during the day and it suppressed my appetite for at least three hours.

A good old fashioned cocaine cocktail…

2011-10-16T00:51:00.001-04:00

What's In Kay's Mind?: A good old fashioned Cocaine cocktail…updated

Exogenous ingestion of melatonin and GABA – this makes sense as dreaming and the processing of the days information begins in REM sleep, so it seems melatonin acts like a re-uptake inhibitor, why I am now unable to sleep well again. I am up to 8-10 mgs melatonin at night plus additional glutamine I take in the evening and during the day as well. The darkness in my apartment during the day is causing a problem although I am compensating somewhat with my LCD computer screen set at Standard. This leads one to think our brains must operate more in a manner of gathering information rather than processing it during the daylight ours which is clearly how our more primitive ancestors would have functioned. This explains the keener insights I have been having during the day as my melatonin stores are being released due to my darker apartment. The walls are antique white versus bright white, which I requested as the apartment faces the east and a significant number of trees so it gets little sunshine but lots of heat.

Is this why we have numerous cases of chronic fatigue syndrome? Does melatonin work like a dissociative, as do many cough medicines and why we are so affected by the wake/sleep cycles of others to whom we are psychically connected. This means that during the day we tend not to dissociate unless we have been traumatized by some event of which we are unable to deal, then we slow down and take to our beds for a few days. At night when the sun begins to set [in the case of primitive people their sleep wake cycles are governed more by the rising and setting of the sun] or rather when we decide to lower the lights and start to relax we might start a process of dissociation, whereby we begin to project our daytime rational selves as melatonin is being released into our brains and our bodies become relaxed, catatonic like, and we fall to sleep. This is the reason these chemicals administered exogenously fail over time to promote what they claim as they begin to increase the levels of stimulating chemicals like dopamine despite their other positive effects such as antioxidant activity. The more you take the more you have to take. And, I am guessing, since melatonin has a short half life in the body, about the length of REM sleep, you might awaken after it has been used up, and/or GABA (if levels are adequate) takes over that further increases muscular relaxation, and you then fall into delta sleep. So at once they may act like cocaine but they probably work endogenously in the brain like an orchestra one complementing the other at different times. Therefore one might be better off taking glutamine and tryptophan rather than melatonin and GABA.

Taking it further, this means that with people we are connected to, one might have difficulty sleeping. An example would be having a connection to someone who is a nurse or medical professional who works at night in the bright lights of a hospital. This works fine if you are a day time person and sleep at night. I have experienced this numerous times at my sister’s when visiting and we all are up during the daylight hours. I rarely sleep when I am there, as one of them is always dissociating and I am the recipient of that dissociation. My father experienced this as well despite his blindness although I would guess his melatonin levels depleted after a period of time which affected his ability to sleep at all and became the case. Blind people probably have high levels of melatonin but I am also guessing these deplete unless they consume higher than normal amounts of tryptophan throughout the day.

My experience with consuming tryptophan has been positive and negative. Taken at night tryptophan will induce sleep but after several days of taking it one will become more alert as the sleepy phase wears off and the anti-depressant effects begin to work. The same goes for daytime consumption, there is generally a mild phase of sleepiness followed by greater calm and alertness. It might well be that tryptophan (serotonin) is also causing a degree of dissociation, splitting off the night time drowsiness we experience when we close our eyes and everything becomes dark, so serotonin might be the daytime regulator of melatonin. I have taken it at night frequently and after several days I was simply unable to sleep. I was more energetic and alert. This might all work differently were it not for our psychic connections. I have gone without tryptophan and this makes things work better for me although anorexia becomes an issue as serotonin regulates the hypothalamus which controls appetite, thirst, body temperature, etc. I have also taken a combination of tryptophan, glutamine and vitamin C which was highly effective at helping me sleep.

One evening while viewing the National Geographic video on Sleep Walking, I was struck by the gentleman’s case in which he was charged with the brutal murder of his wife. My first impression was that his neighbor was involved and might have unknowingly affected the man’s behavior. I had been reading and learning about projection and projective identification during that time [who are you?]. As the story unfolded I learned he had difficulties on his job and may have experienced primitive negative thoughts about his boss he could easily have acted out on his wife in a state of sleepwalking. Maybe he was simply having an affair and wanted to get out of his marriage, but why not get a divorce? Why not just leave? Divorcing or leaving are rational ways of dealing with a problem including leaving his job. Fixing a pool pump in the middle of the night is irrational but on a Saturday afternoon would be quite rational.

On thinking of this matter in the context of my own life, I recently discovered I might be connected to a woman who is from Chapel Hill. In 1977, after an evening out at a night club, I had a little more to drink than usual and fell asleep on the sofa. I had wet the sofa or bed in my youth and was admonished for it, so I developed repressed memories I expressed as anxiety about falling asleep and the fear of becoming too relaxed in order to keep from wetting the bed and I was a bed wetter until age 12. As a result, that night after drinking too much, I must have had to go to the bathroom, of which I have no recollection, took a white ashtray off the coffee table, placed it on the floor and urinated in it. I did it in this manner because during the late 60’s we had to use porcelain pots to go to the bathroom as we lived in a house with no bathroom for several months. This resolved the mechanics of my actions but not the why of the event. I recently learned my current neighbor who I knew nothing of at the time, during a time of racial unrest, had been stopped from using the public restroom in a local store and was asked to leave. She left the store, got drunk, returned and proceeded to urinate in front of the store. This is as she related her experience to me. She was subsequently arrested by the sheriff (William Blake, sheriff of Orange County, NC, possibly related to my grandmother Eunice Blake) and jailed for one night. I had been jailed overnight in 1977 as well, so this means the drama in which I was involved, had been interrupted, not only was it interrupted, I was completely unconscious of the events occurring in my waking life which led to my behavior that night. I fully believed I was acting of my own will, except for that night. And since this discovery I have located a street, Perly Street, in a small town in Massachusetts with the same last name as my neighbor. I had been in Medford, Massachusetts briefly in 1975 after being discharged from the US Army and so the story goes on further into history, probably pre-Civil War.

Is there a relationship between Cruetzfeldt’s disease and a calcified pineal…

2011-09-30T13:25:00.001-04:00

I consumed a significant amount of a cal/mag/zinc supplement for several years preceding my inability to sleep. I also think it was having taken the GABA while living at Woodburn in Raleigh which caused me to start acting out the mind I was possessed of, that was consumed by a severe paranoia. Was it Skinner? Was it some of his patients? Was it Mary Jane Kelley, Martha Tabram or any of the other Ripper Victims?

Diet and evolution…

2011-09-15T13:58:00.001-04:00

Evolutionary Psychiatry: Your Brain on Ketones

What I think about when I start getting confused about which is best, carb or fat, I consider how our brains may have developed. I think about octopi and squid who consumed large amounts of protein and no carbs at all. 0.7 grams of every gram of protein gets converted to carbs. Clearly high protein and low fat is the key to better health and the development of a healthier brain since it was this habit that evolved the human brain to begin with. I just read that manganese must be present for glutamate to be converted into glutamine so it then can be converted to GABA. Minerals the all important key. Taurine, another amino acid derived from methionine, shuttles potassium into the cell and sodium out. I have to agree with the body builders this time that a higher ratio of protein to carbs and fat is the key to better health. The key is the amounts consumed at one time with more frequent consumption. While Karen Carpenter was the extreme of the high protein diet, there is much to be said for it in keeping other conditions under control.

Fat Loss

ABC Body Building

Protein

So melanin affects this hormone as well as it inhibits sexual arousal…

2011-09-15T12:42:00.001-04:00

Melanocyte-stimulating hormone - Wikipedia, the free encyclopedia

Vitamin E…

2011-09-14T16:09:00.001-04:00

broke down (softened) the rubber stopper on the bottle of Liquid E I purchased several years ago. What about using something like that to degrade old tires. Probably wouldn’t be cost effective to use Vitamin E but maybe something similar.

My rash…

2011-09-14T14:13:00.001-04:00

Young men who were fed a low-manganese diet developed decreased serum cholesterol levels and a transient skin rash

Linus Pauling Institute at Oregon State University

Fat was not being metabolised. Several applications of coconut milk 14 gms fat cured the problem.

Obesity and the regulation of fat metabolism - WormBook - NCBI Bookshelf

2011-09-14T01:30:00.001-04:00

Obesity and the regulation of fat metabolism - WormBook - NCBI Bookshelf

I think tryptophan also contributes to obesity…updated

2011-09-14T00:01:00.001-04:00

…I was not taking this supplement while taking the taurine but I have taken it frequently over the past several years and my appetite has increased and I am at 170 lbs and only 5’3” tall although I have gained considerable muscle mass my body mass index is at about 38 meaning I have 50 lbs of fat I do not need.

I am eating right at my basal metabolic rate of about 1000-1200 calories per day.

In consuming high levels of leucine, the fat packed on to the tummy and glutteous maximus rather than being burned as fuel. So I am taking just the essential aminos, eating oatmeal and one meal in the evening right now.

Re: Taurine mimicking GAPHD inactivation…update 3

2011-09-13T23:56:00.001-04:00

What's In Kay's Mind?: Is taurine mimicing this inactivation…

…could this have contributed to my mother’s second husband’s cancer? He was very thin and ate lots of fish and shrimp all high in taurine, in addition to smoking several packs of cigarettes per day.

The nicotine blocked the hunger messages from reaching his frontal lobes….

Is taurine mimicing this inactivation…

2011-09-13T23:51:00.001-04:00

Genetic alterations of metabolic enzymes profoundly impact fat levels in C. elegans. For example, RNAi inactivation of key glycolic and gluconeogenic genes such as GAPDH, an insulin-regulated glycolytic enzyme, and PEPCK, a regulated enzyme of gluconeogenesis and glyceroneogenesis, cause fat reduction (Ashrafi et al., 2003).

Obesity and the regulation of fat metabolism - WormBook - NCBI Bookshelf

This is how I lost the weight with the taurine…

2011-09-13T15:18:00.001-04:00

Hypothalamic ATP-sensitive K + Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses

I mixed it with buffered Vitamin C from Jo Mar which contains potassium.

I have been taking Melatonin for about three years now…

2011-08-30T13:54:00.001-04:00

My blood pressure was around 110/60 for many years in my youth…

2011-08-30T13:52:00.001-04:00

What's In Kay's Mind?: My right carotid pulse is definitely lower than on the left…

…this tells me that I was definitely on the right side of someone’s mind.

My right carotid pulse is definitely lower than on the left…

2011-08-30T13:48:00.001-04:00

Influences of melatonin administration on the circulation of women

Melatonin and dreaming…updated

2011-08-30T13:47:00.001-04:00

…acts like a psychotropic.

I have been drinking one cup of coffee in the AM. I have been taking 3-6 mgs melatonin internally and 2-5 mgs under the tongue for the past several months and I am dreaming again. In addition to this I took 2mg chlorpheniramine maleate plus some glycine earlier in the evening. I have been sleeping better than ever. I have also had to reduce the amount of protein I consume in the evenings.

I take the chlorpheniramine maleate because the amino acids I take also contain histidine which can keep one awake. I don’t think it is necessary.

I have also taken this in conjunction with glutamine which does not seem to work as well.

I took three mgs earlier than usual and I was able see things going on in my mind. I thought it was the Abilify but I stopped taking it months ago.

I have also been taking tryptophan, 500 mgs, daily in the AM.

Melatonin instead of GABA might have a powerful effect on the release of growth hormone.